[indices] Tigecycline (Tygacil)[2]

["Lee Baker" <leebaker@iafrica.com>]

Hi, 
herewith an extract on the safety profile of Tigacycline.

Regards
Lee Baker
Amayeza Info Services
South Africa

Extracted from P&T Quik report - Micromedex 2006
WARNINGS (1):
-  Glycylcycline class antibiotics are structurally similar to
   tetracycline class antibiotics and may have similar effects.
-  May cause fetal harm when administered to a pregnant woman.
-  May cause permanent discoloration of the teeth (yellow-gray-brown)
   if used during tooth development (last half of pregnancy, infancy,
   and childhood to the age of 8 years).
-  Should be administered with caution in patients with known
   hypersensitivity to tetracycline class antibiotics.
-  Pseudomembranous colitis has been reported with nearly all
antibacterial agents and may range in severity from mild to
life-threatening, therefore, it is important to consider this
diagnosis in patients who present with diarrhea subsequent to the
administration of any antibacterial agent.

ADVERSE EFFECTS (1):
                                   Tigecycline     Comparators
Most common, > 5%
  Nausea                           29.5%           15.8%
  Vomiting                         19.7%           10.8%
  Diarrhea                         12.7%           10.8%
  Local reaction to procedure       9.0%            9.1%
  Infection                         8.3%            5.4%
  Fever                             7.1%            9.8%
  Abdominal pain                    6.8%            5.7%
  Thrombocythemia                   6.1%            6.2%
  Headache                          5.9%            6.5%
  SGPT increased                    5.6%            4.7%

Less common, 2-5%
  Hypertension                      4.9%            5.6%
  Hypoproteinemia                   4.5%            3.0%
  SGOT increased                    4.3%            4.4%
  Anemia                            4.2%            4.8%
  Lactic dehydrogenase increased    4.0%            3.5%
  Pain                              3.7%            2.9%
  Leukocytosis                      3.7%            2.5%
  Cough increased                   3.7%            3.8%
  Alkaline phosphatase increased    3.5%            2.6%
  Healing abnormal                  3.5%            2.6%
  Dizziness                         3.5%            2.7%
  Peripheral edema                  3.3%            3.3%
  Abscess                           3.2%            2.6%
  Amylase increased                 3.1%            1.4%
  Dyspepsia                         2.9%            1.6%
  Dyspnea                           2.9%            2.7%
  Constipation                      2.8%            4.1%
  Pruritus                          2.6%            4.1%
  Asthenia                          2.5%            1.7%
  Rash                              2.4%            4.1%
  Hypotension                       2.3%            1.7%
  Bilirubinemia                     2.3%            0.9%
  Insomnia                          2.3%            3.3%
  Sweating                          2.3%            1.6%
  BUN increased                     2.1%            0.2%
  Hypokalemia                       2.1%            2.9%

DRUG INTERACTIONS (1):
-  Oral contraceptives
-  Warfarin