INDICES> Wisconsin solution (2)

["amayeza" <amayeza@pharmail.co.za>]

Indices: Wisconsin solution (2)

  Dear Huma,

  I have found some info on Wisconsin solution on a database called UpToDate
(see info below) As you will see, it is also known as Viaspan. I have
 attached the information on Viaspan' s composition and availability from
 Micromdex.

  I hope this information is of use to you.

   Yours sincerely
   Lee Baker

   Medicine Information Pharmacist - Amayeza Info Services.

   Preservation solution - The activity of the main cellular enzymatic pump,
Na-K ATPase, decreases during storage [48]. Cell swelling occurs as sodium
moves along its concentration gradient into the cell and is followed by
water. Two kinds of preservation solutions have been used to counteract this
tendency:


Intracellular-type crystalloid solutions that are high in potassium and  low
in sodium (Euro-Collins solution and University of Wisconsin solution)
 Extracellular-type solutions combined with a nondiffusible colloid,
usually dextran (Celsior solution and Cambridge solution)

 The University of Wisconsin solution has been used extensively in liver
and kidney transplantation and has extended the preservation time for these
 organs, but modified Euro-Collins solution is currently the most widely
used  perfusate in lung transplantation [45,46,48,49].

 CADAVERIC KIDNEYS - Much of the time, a number of different organs will be
recovered from a single cadaveric donor, potentially including the heart,
lungs, liver, pancreas, kidneys, and intestine [2,3]. The kidneys can be
reliably predicted to be the last organs to be removed.


 Technique - The cadaveric donor will have been given heparin and possibly
phentolamine (to promote vasodilatation) prior to aortic cross clamping. Via
a cannula placed in the distal aorta, the kidneys are kept cold by an
in-situ flush with an intracellular type of preservation solution. In the
 United States, the most popular is the University of Wisconsin (Viaspan®)
solution. The kidneys are usually not seen or mobilized prior to aortic
 cross clamping, as such manipulation can adversely affect the liver.

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