INDICES> Turinal (5)

["Janet McNeece" <Jmcneece@mail.rah.sa.gov.au>]

Indices - Turinal (5)

To add to the information given by Kirsten on the 14th Oct 2003   There 
is a meta-analysis of randomized control trials of  progestational 
agents in pregnancy in the British Journal of  Obstetrics and 
Gynaecology March 1989 Vol 96 pp265-274.  This  study concluded that the
meta-analysis failed to provide  convincing evidence of the efficacy of 
progestational agents  for the maintenance of pregnancy.  Since there is
evidence of  hormonal imbalance in some women with recurrent miscarriage
  any trials of progestogens should include only women with  
demonstrated hormonal abnormalities who are carrying a live foetus  as 
shown by ultrasonography.  I have found no studies which show  any 
substantial efficacy for progestogens (even in women with  hormonal 
imbalance).  Reprotox however does review the possible  second 
generation toxicity and the evidence appears to indicate  that there is 
little increase in risk.  
It is interesting to note that the use of allylestrenol in Japan  
appears to be limited to the treatment of benign prostatic  hypertrophy 
rather than to treat threatened abortion. 
Hope this information adds to your knowledge 
Janet Mcneece 
Senior Pharmacist 
Medicines Information 
Royal Adelaide Hospital 

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