INDICES> Turinal (2)

["Kirsten Myhr" <kirsten.myhr@relis.ulleval.no>]

Indices: Turinal (2)

Manufacturers of allylestrenol:

Gestanin® Organon, GB
Gestanon® Organon, AT, BE, CH, ES, IT, LU, PL, TR
Gestormone® Zorka, PL, YU
Maintane Tab.® Jagsonpal, IN
Orageston® Akzo, BR
Premaston® Kalbe, ID
Profar® Infar, IN
Turinal® Gedeon Richter, HU, PL
Turinal® Medimpex, CZ
Turinal® Mekim, HK

I think the Martindale profile states its role clear enough:
Allylestrenol is a progestogen (see Progesterone, Ref.) structurally related
to progesterone that has been given in threatened and recurrent miscarriage,
and to prevent premature labour. However, with the exception of proven
progesterone deficiency, such use is no longer recommended. In threatened
miscarriage in progesterone-deficient women a suggested dose is 5 mg three
times daily by mouth for 5 to 7 days.
A case-control study of allylestrenol use in pregnancy during 1980 to 1984
in Hungary indicated that it was not teratogenic. (1)
1. Czeizel A, Huiskes N. A case-control study to evaluate the risk of
congenital anomalies as a result of allylestrenol therapy during pregnancy.
Clin Ther 1988; 10: 725-39.

Unfortunately, companies, be it multinationals such as Organon or nationals
such as Gideon Richter in  Hungary, continue to manufacture unsafe and
obsolete drugs in any country where the regulatory authority has not banned
them. Manufacturers feel no responsibility in such issues. This again
stresses the importance of a strong regulatory authority and of activist
groups such as consumer movements to lobby governments.

Kirsten Myhr, MScPharm, MPH
Head, RELIS Ost Drug Information Centre
Ulleval University Hospital
0407 OSLO, Norway
Tel: +47 23 01 64 11  Fax: +47 23 01 64 10
kirsten.myhr@relis.ulleval.no (w)
www.relis.no

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