INDICES> Treatment of uncomplicated malaria (3)

["Dr. Douglas Ball" <dball@hsc.kuniv.edu.kw>]

Indices: Treatment of uncomplicated malaria (3)


I have no experience with the proposed combination and a quick
literature search did not yield any supporting articles other than their
use together in vitro. Given that both these agents can increase QT
interval I would be concerned about using them together in patients
especially in uncomplicated malaria. Essentially it will come down to
risk/benefit - how severely ill is the patient, what alternatives are
available given the parasite resistance profile, what facilities are
available for cardiac monitoring and resuscitation, etc. Personally, I
would not recommend it on the basis of alternative treatments being
available of lower risk.

Regards

Douglas Ball

Dr. Douglas Ball PhD
Dept. of Pharmacy Practice
Faculty of Pharmacy, Health Sciences Center
University of Kuwait, PO Box 24923 Safat 13110
Kuwait
Tel: (965)531-2300 ext. 6048
Fax (work): (965)534-2807
Fax (private): (1) 775-860-0325
E-mail: dball@hsc.kuniv.edu.kw  

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