INDICES> Treatment of uncomplicated malaria.

["Sofia Salas" <salassofia@hotmail.com>]

Indices: Treatment of uncomplicated malaria. 


I would like to know what is your opinion about the use of two drugs
together: azithromycin plus chloroquine for treatment of the
uncomplicated plasmodium falciparum malaria. The problem is that the
literature not recommends The concurrent administration of
erythromycin or clarithromycin  and chloroquine, due to Chloroquine
and clarithromycin or erythromycin  have been shown to prolong the QTc
interval at the recommended therapeutic dose and it could be due to
additive effects on QT prolongation. The doses are azythromycin 1g per
day for three days and chloroquine 600mg base for three days, so the
total doses are 3 g for azithromycin and 1800 mg for chloroquine base.
Do you have some experience with this combination? Do you think this
combinations could be dangerous? Could do the clinical trial? What is
your opinion about this combination?

Thanks you

Sofia Salas
Pharmacist
Peru

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