INDICES> aspartame (2)

[Helpline <helpline@thenetwork.org.pk>]

INDICES> aspartame (2)
------------------------------

Dear Sylvester,

According to information on MICROMEDEX CD and a search on Medline reveals
that aspartame can be successfully used in non-insulin dependent diabetics
with no
alteration of diabetic control attributable to aspartame.  Some literature
reports and references are give below to substantiate the safe use of
aspartame
in diabetics.

LITERATURE REPORTS:

The effects of aspartame were evaluated over a 90-day period in 43 men and
women age 21 to 70 with non-insulin-dependent diabetes. These patients
ingested
1.8 g of aspartame each day, which is considerably higher than the
estimated
average ingestion of aspartame (0.5 g). There was no evidence of
deterioration
of diabetic control or increases in plasma phenylalanine levels above 4
milligrams/deciliter (Stern et al, 1976).

References:
1. Nehrling JK, Kobe P, McLane MP et al: Aspartame use by persons with
diabetes. Diabeties Care 1985; 8:415-417.

2. Stern SB, Bleicher SB, Flores A et al: Administration of aspartame in
non-insulin-dependent diabetics. J Toxicol Environ Health 1976; 2:429-439.

3.Metabolic effects of adding sucrose and aspartame to the diet of subjects
with noninsulin-dependent diabetes mellitus.
Colagiuri S, Miller JJ, Edwards RA. Am J Clin Nutr 1989 Sep;50(3):474-8

4. Filer LJ Jr, Stegink LD. Aspartame metabolism in normal adults,
phenylketonuric heterozygotes, and diabetic subjects. Diabetes Care 1989
Jan;12(1):67-74

5. Shigeta H, Yoshida T, Nakai M, Mori H, Kano Y, Nishioka H, Kajiyama S,
Kitagawa Y, Kanatsuna T, Kondo M, et al. Effects of aspartame on diabetic
rats
and diabetic patients. J Nutr Sci Vitaminol (Tokyo) 1985 Oct;31(5):533-40

6.  Okuno G, Kawakami F, Tako H, Kashihara T, Shibamoto S, Yamazaki T,
Yamamoto
K, Saeki M. Glucose tolerance, blood lipid, insulin and glucagon
concentration
after single or continuous administration of aspartame in diabetics.
Diabetes
Res Clin Pract 1986 Apr;2(1):23-7

About its use in people using aspartame to reduce weight, its use can
reduce
calorie intake.  Two studies are quoted below:

1. Blackburn GL, Kanders BS, Lavin PT et al: The effect of aspartame as
part of
a multidisciplinary weight-control program on short- and long-term control
of
body weight. Am J Clin Nutr 1997; 65(2):409-418.

2. Porikos KP, Booth G & Van Itallie TB: Effect of covert nutritive
dilution on
the spontaneous food intake of obese individuals: a pilot study. Am J Clin
Nutr
1977; 30:1638.

Regards.

Ayesha Ahmed
Drug Information Officer
Pakistan
helpline@thenetwork.org.pk



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