INDICES> aminophylin + papaverin? (2)

["Dr.L.Offerhaus" <lo@euronet.nl>]

INDICES> aminophylin + papaverin? (2)
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> Is it OK to mix aminophyliin and papaverin powder for oral preparation
> ? Is there any interaction between them ? How about the stability of
> the mixture ? All your responses will be helpful for us. Thank you.

> [moderator comment: oral aminophyllin? I thought that was erratically
> absorbed? What indication for this combination? Wilbert Bannenberg,
> acting moderator]

Dear colleague,

I fully agree with the moderator's comments - For oral papaverine 
there is no valid indication. Its only proven use is as intracavernous 
injection in erection impotence. Oral aminophylline is no longer 
used; its absorption is lower than anhydrous theophylline and erratic 
and, as it is quite basic, it causes frequent gastrointestinal problems. 
These drugs in their oral form should no longer be used, certainly 
not in combination. So the pharmaceutical question should not be 
asked.

Best wishes,

Dr.L.Offerhaus
Koedijklaan 1a, NL-1406KW Bussum, The Netherlands
Phone: +31-35-6923288.  Fax: +31-35-6923290
E-mail: LO@EURONET.NL  CompuServe disconnected from 1/3/2001


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