INDICES> Isoniazid Suspension (cont)

[David Woods <DavidWoods@healthotago.co.nz>]

INDICES> Isoniazid Suspension (cont)
------------------------------------

The following formula has been published in the BPC (1973) and the 29 th
edition of Martindale. As far as I know no formal stability studies have
been carried out.

50 mg per 5 mL

Isoniazid powder BP         50    mg
Citric acid monohydrate     12.5  mg
Sodium citrate              60    mg 
Concentrated anise water     0.05 mL (optional)
Glycerol                     1    mL
Parabens                     0.1  %  (ie 0.1% total parahydroxybenzoates)
Water     to                 5    mL 



The original formaula contained chloroform water as a preservative. I have
suggested parabens instead.
Suggested expiry date 30 days.

Storage
Less than 25 C but refrigeartoion may cause crystallisation of isoniazid
from solution. Protect from light.

NB
Do not use syrups (glucose, sucrose etc)in the formaulation due to
incompatibility with isoniazid.


David Woods
Drug Information Pharmacist
Dunedin Hospital
Dunedin
NEW ZEALAND
DavidWoods@healthotago.co.nz

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