INDICES> Quinine syrup formulation?

[Joint Medical Stores Uganda <did.jms@imul.com>]

INDICES: Quinine syrup formulation?
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[rerouted from E-drug due to its technicalities involved; WB]

Question:

What is the correct formulation of manufacturing Quinine syrup
(10 mg/5 ml)using Quinine Hcl powder?

With the knowledge that the solubility of Quinine HCl powder in water is
1:23,I am using the following formulation:


Ingedient                        Quantity 

1.Quinine Hcl powder             1960 g.
2.Parabene concentrate           192 ml
3.Anise water BP                 0.8 L
4.Yellow colour                  qs(0.8 g)
5.Sugar syrup(65%)               30.8 L
6.Water                          46 L

Batch size: 80 L

Procedure:

After dissolving Quinine HCl powder in 10 L of hot
water, a balance of 36 L water (cold) is added.
While continiously mixing, 30.8 L of Sugar syrup is added, then 0.8L of
anise water.
On obtaining a homogenous mixture Parabene concentrate is added.
The volume is made up to 80 L.

Problem

On settling , this Quinine syrup forms a precipitate
on the bottom of the vessel.

Why is this so?
What should be done to rectify this problem?

Thank you for your kind assistance.

Fred Mukasa
Pharmacist, JMS Production Unit
P.O.Box 4501
Kampala
Fax: ++ 256 41 267 298

Email: did.jms@imul.com  [manually added by moderator; WB]
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