INDICES> Date: Wed, 5 Jan 2000 12:37:01 +0200

["Leesette Turner" <hamis@iafrica.com>]

To: indices@usa.healthnet.org
From: "Randy Trinkle" <rtrinkle@rosencrantz.citytel.net>
Subject: INDICES> Jetepar Identification (3)



Jetepar Identification (3)




Advances Volume 12 No.5

September/October 1995 Efficacy of Glucuronates Versus Placebo in
Chronic Hepatitis: A Randomized, Double-Blind Study F. Migijo, M.D.,
L.C. Rovati, M.D.,  A. Santoro, Ph.D. ABSTRACT This randomized,
placebo-controlled, double-blind, six-parallel-group study assessed
how adults with alcohol-induced chronic hepatitis responded to betaine
glucuronate, diethanolamine glucuronate, and nicotinamide ascorbate
(**Jetepar**). Two hundred patients participated in the 4-week study;  100
received Jetepar in capsule, syrup, or intravenous (IV) form daily, and 100
received placebo in capsule, syrup, or IV form daily.

Results of physical examination and laboratory anallysis performed at
the start and end of the study indicated that Jetepar was more
effective than placebo in improving blood chemistry parameters
(phosphatase, bilirubin, and triglyceride levels) and urinalysis
values (bilirubin and urobilinogen levels) and in reducing jaundice,
edema, itching, headache, anorexia, dyspepsia, nausea, and vomiting.


Hepatomegaly and megalosplenia also improved slightly in patients
taking Jetepar. Patients given placebo worsened. The drug was well
tolerated, and no differences in therapeutic effect were noted among
the three forms. Keywords: alcoholic hepatitis; serum enzymes;
glucuronic acid; etaine; diethanolamine; nicotinamide; ascorbic acid

***************************************
>>Randy Trinkle, BScPharm, BA
>>Pharmacy Department
>>Prince Rupert Regional Hospital
>>Prince Rupert, BC
>>mailto:rtrinkle@mail.citytel.net
>>Health Science links:
>>http://www.rupert.net/~rtrinkle
>>***************************************
>>
>>I'll only say this once.  1999 is NOT the
>>last year of the 20th century.
>>


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