INDICES> Re: silver sulpha formulation

["Randy Trinkle" <rtrinkle@rosencrantz.citytel.net>]

> A pharmacist friend of mine in-charge of drug production unit (local
> production) has a problem of silver sulfadiazine cream 1% which turns grey
> after a month or so although it is packed in an opaque plastic container
> tightly closed.

> He would like to know the cause. If it is oxidation, will the addition of an
> anti-oxidant citric acid 0.5% resolve the problem? How will this acid affect
> the application of this cream on an open burnt wound? 

The commercial products available in Canada don't contain an
antioxidant, but there is an advisory to protect from light and
discard if the cream darkens.  The problem could be the excipients
being used.

One of the products lists the following as nonmedicinal ingredients:

isopropyl myristate, methylparaben, polyoxyl 40 stearate, propylene 
glycol, purified water, sodium hydroxide, sorbitan monooleate, 
stearyl alcohol and white petrolatum.

***************************************
Randy Trinkle, BScPharm, BA
Pharmacy Department
Prince Rupert Regional Hospital
mailto:rtrinkle@mail.citytel.net
Health Science links:
http://www.rupert.net/~rtrinkle
***************************************

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