INDICES> silver sulpha formulation

[Joint Medical Store <storejms@imul.com>]

To Indices 

A pharmacist friend of mine in-charge of drug production unit (local
production) has a problem of silver sulfadiazine cream 1% which turns grey
after a month or so although it is packed in an opaque plastic container
tightly closed.
The ingredients used are: silver sulfadiazine powder 30g, cetomacrogol 1000
? 50g, cetostearyl alcohol 400g, Cetiol V 600g, solutio sorbitoli 70% -
120g, sorbic acid 6g and water to 3kg.
He would like to know the cause. If it is oxidation, will the addition of an
anti-oxidant citric acid 0.5% resolve the problem? How will this acid affect
the application of this cream on an open burnt wound? 

Thank for your kind help in advance.

Sr. Rovina Turyazayo, Pharm. D.
JMS Drug Information Desk
P. O. Box 4501, Kampala
E-mail;    HYPERLINK "mailto:storejms@imul.com";   storejms@imul.com 
Fax; 256 41 267 298




--
Send mail for the `INDICES' conference to `indices@usa.healthnet.org'.
Mail administrative requests to `majordomo@usa.healthnet.org'.
For additional assistance, send mail to:  `owner-indices@usa.healthnet.org'.