Re: INDICES> "SILVER SULPHADIAZINE"

["Dr.L.Offerhaus" <lo@euronet.nl>]

Dear Colleague,

The best critical review can be found on p. 827 of the last edition (5, 
1997) of Kucers et al.: The Use of Antibiotics - the most authorative 
textbook.

The main points are that it is very effective (in controlled trials) to 
prevent sepsis, particularly due to St.aureus. It can be used on 
uninfected burns; some hospitals combine it with 0.2% 
chlorhexidine. In one trial there was an emergence of sulfonamide-
resistant enterobacteriae. Some say it prevents Pseudomonas 
infections, but others say that since 1980 Pseudomonas has been 
on the increase in treated patients.

Theoretically use of the cream can elicit sulfonamide 
hypersensitivity, but precise data on incidence are not available.

Dry open exposure to laminar flow in a sterile environment is better, 
but that is a theoretical option in Africa.

Best wishes,
Dr.L.Offerhaus
Koedijklaan 1a, NL-1406KW Bussum, The Netherlands
Phone: +31-35-6923288.  Fax: +31-35-6923290
E-mail: LO@EURONET.NL  CompuServe: 71530,15
Eur J Clin Pharmacol ONLY:
POB 75552, NL-1070AN Amsterdam, The Netherlands


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