INDICES> Chloroquine injection--photodegradation

["Randy Trinkle" <rtrinkle@rosencrantz.citytel.net>]

The following indicates that photodegradation has
been studied.  The full paper should give you an
idea of storage/packaging requirements and provide
other references:

J Pharm Biomed Anal 1994 May;12(5):667-74 

Photodegradation studies on chloroquine phosphate by
high-performance liquid chromatography.

Karim EI, Ibrahim KE, Abdelrahman AN, Fell AF

Department of Pharmaceutical Chemistry, Faculty of Pharmacy,
University of Khartoum, Sudan. 

A method based on high-performance liquid chromatography (HPLC) was
developed to study degraded chloroquine samples produced after
exposure to sunlight in the Sudan. The method was also used to
investigate chloroquine photodegradation after irradiation by UV and
sunlight at ambient temperature. The study showed that the
photodecomposition of chloroquine was pH and solvent dependent.
Moreover, the extent of reaction was found to increase in the absence
of oxygen. At pH 8, where the reaction rate was high, the
photodecomposition was found to follow pseudo-first-order reaction
kinetics. The HPLC method developed was also employed to analyse
chloroquine and its degradation products in two commercially available
brands of chloroquine injections which had been stored under local
conditions in the Sudan. A number of degradation products were
separated and examined by photodiode array spectroscopy and
preparative TLC. 

***************************************
Randy Trinkle, BScPharm, BA
Pharmacy Department
Prince Rupert Regional Hospital
mailto:rtrinkle@mail.citytel.net
Health Science links:
http://www.rupert.net/~rtrinkle
***************************************


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