INDICES> Re: Proton pump inhibitors

[owner-indices@usa.healthnet.org]

> We would be so grateful if you could give us any information about side
> effects of proton pump inhibitors.

>From an official monograph for omeprazole:

The following adverse experiences (at a rate of more than 1%) have
been reported in individuals receiving
 omeprazole therapy in controlled clinical situations: nausea (3.6%);
 headache (2.6%); diarrhea (2.9%); constipation (1.4%); abdominal pain
 (2%); dyspepsia (2.2%); flatulence (2.4%) and vomiting (1.9%). Skin
 rash, urticaria and/or pruritus have occurred in a few patients. In
 addition, the following adverse events were reported in clinical
 trials or were reported from routine use: Skin: In isolated cases
 photosensitivity, erythema multiforme and alopecia. Musculoskeletal:
 In isolated cases arthralgia, muscular weakness and myalgia. Central
 and Peripheral Nervous System: Rarely dizziness, paraesthesia,
 somnolence, insomnia and vertigo. In isolated cases reversible mental
 confusion, agitation, depression, and hallucination occurring
 predominantly in severely ill patients. Gastrointestinal: In isolated
 cases stomatitis and gastrointestinal candidiasis. Hepatic: In
 isolated cases encephalopathy in patients with pre-existing severe
 liver disease, hepatitis with or without jaundice and hepatic
 failure. Endocrine: In isolated cases, gynaecomastia. Other:
 Hypersensitivity reactions including, in isolated cases, angioedema,
 fever and bronchospasm. In isolated cases increased sweating,
 peripheral oedema, blurred vision and taste perversion. An extensive
 evaluation of laboratory variables has not revealed any significant
 changes during treatment which are considered to be clinically
 important. Laboratory abnormalities were reported as serious adverse
 events in 0.2% (13/7 356) healthy subjects and patients exposed to
 omeprazole. In no case was a causal relationship to the drug
 established. A slight, clinically insignificant increase in alkaline
 phosphatase, S-ASAT and S-ALAT has been observed. Similar increases
 were also observed with histamine H2-receptor antagonist treatments
 in comparative studies. In isolated cases, patients have developed
 leukopenia, thrombocytopenia and, in rare cases, increased liver
 enzyme levels.

>  We are also wondering if there are any new medicines containing live bacteria
>  or their metabolites to maintain intestinal microflora's balance.

Health food stores (sic) sell a variety of products with either
Lactobacillus acidophilus or Lactobacillus salivarius.

***************************************
Randy Trinkle, BScPharm, BA
Pharmacy Department
Prince Rupert Regional Hospital
mailto:rtrinkle@mail.citytel.net
Health Science links:
http://www.rupert.net/~rtrinkle
***************************************

'What's the most important thing in life to you?'

Data.

'No, no--I mean, what makes you happy, satisfied?'

Good data.


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