INDICES> isoniazid/chloramphenicol interactions

["Judith Mackson" <judmac@bigpond.com>]

Tammy Priest, in the Western Province, Papua New Guinea, who 
asked:
 
I have a drug information question-if you have time would 
you mind seeing if you can find some information?  We had a 
lady on TB treatment (INAH, rifampicin, pyrazinamide) and 
chloramphenicol PO for pneumonia.  She developed SLE 
butterfly rash ? secondary to INAH.  I am wondering if there
is any info regarding which CYTP450 isoenzyme CMP is a 
substrate for and which ones it inhibits/induces.  We have a 
Martindale 29 here which I have  looked in.  It has some 
info re CMP interactions-nothing that helps with
regard to INAH however.  I am wondering that now the CMP 
is finished, will it be safe to reintroduce INAH after the 
reaction clears up.  We have changed her to ethambutol 
currently.

CMP is the DRUG OF CHOICE for most infections 
here-unfortunately other standard therapies include 
aminophylline, phenobarbitone, phenytoin, cimetidine....!
 Basically a drug interaction cacophony.  

Please reply to Tammy directly at ko9smtp@copoktd.bhp.com.au
Many thanks

Judith Mackson
 Prescribing Program Coordinator
 National Prescribing Service Ltd
 9 Leichhardt Street, Darlinghurst NSW 2010
 Australia
 
 



ustralia
 
 



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