INDICES> Creatine - Safety and efficacy information

["Mehta, Ushma" <umehta@uctgsh1.uct.ac.za>]

Dear Colleagues

The South African Medicines Control Council (MCC) is currently 
reviewing the registrability of creatine-containing products in South
Africa. In South Africa they are  commonly used by athletes and
body-builders. Medicinal claims such as weight gain in AIDS patients
and the elderly have been made. In some countries it is classified as
a food while in other countries it is registrable as a medicine at
high doses (i.e. doses >3g/day) or when it is used for clinical
conditions such as AIDS.  

We would like to know whether there are any clinical trials currently
underway or recently completed which examine the benefits and risks of
creatine-containing products both in the long and short term. In 
addition, is there any post-marketing data on the safety of such 
products at doses used (doses recommended by manufactureres have 
ranged from 2g/day up to 30g/day).   

Kindly submit all your responses directly to me and I will compile
them for Indices  once I have received all of them. 

Thanks in advance
Ushma Mehta 
====================================================
Ushma Mehta                                   
National Adverse Drug Event Monitoring Centre: MCC 
c/o Department of Pharmacology                
University of Cape Town                       
Observatory,7925                               
South Africa                                  
Tel: (+27-21) 471 618                           
Fax: (+27-21) 448 6181                         
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