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["Department of Pharmacology, Faculty of Medicine, Colombo"@usa.healthnet.org]

<phrm_cmb@slt.lk>
Subject: INDICES> TB therapy - ADR
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To whom it may concern

We have had the following ADR reported following the use of  anti TB
therapy.

 A  Female child of eleven years with a history of tuberculosis was given
anti TB drug therapy which included rifampicin, ethambutol, pyrazinamide
and isoniazid for 3 months. While on therapy she developed thrombocytopenia
and oral and vaginal  bleeding.  Rifampicin was stopped and the platelet
count picked up initially  around  day 6. But  after another   7 days the
platelet count started to fall again and the child developed haemoptysis,
although she was not on rifampicin.  

We have done a search of the literature at our disposal. In the documented
cases of thrombocytopenia there is no record of  relapse after therapy has
been stopped. According to what we have read complete recovery  is usually
seen within 7 - 14 days of stopping the drug. Can you  advice us on this
problem.   Is this a case of drug induced thrombocytopenia or could this be
a case of idiopathic thrombocytopenia.

Please send us a quick reply if it is not too much of a bother. I am also
attaching the tentative reply given to the consultant. Please feel free to
give me a positive feedback  on  it.(   - I had to delete this aspect 
of the message - not readable - moderator)

Thanks

Rohini Fernandopulle
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