INDICES> super-hydration with erythromycin

["Randy Trinkle" <rtrinkle@rosencrantz.citytel.net>]

Apologies for cross-posting.

The surgeon at our hospital--during a consult with
an internist at another site--was told that a liter
of IV fluid had to be given with each dose of IV
erythromycin.  He was given to understand by the
internist that erythromycin is poorly distributed
and taken up by target organs, and that it was
necessary to provide a large amount of fluid in order
to overcome this.  He (of course) asked me if I knew
anything about this.  Shuffling and smiling, I owned
that the only characteristic of this drug that I knew
of that has to do with fluid is to give it in enough
to prevent phlebitis.  But a LITER?

I told him I'd look into it.

I've never heard of this (if I have the story straight).
If this is something old, commonplace, and well-known
then shame on me.  Is there any truth to this?

I tried MEDLINE without success, and I couldn't find
anything through a Web search.

Any info out there?

***************************************
Randy Trinkle, BScPharm, BA
Pharmacy Department
Prince Rupert Regional Hospital
mailto:rtrinkle@mail.citytel.net
Health Science links:
http://www.rupert.net/~rtrinkle
***************************************
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