[india-drug] Re: Drug query on Asmon and Buspiron (3)

["Sampada Patvardhan" <dicmspc@yahoo.co.in>]

Drug query on Asmon and Buspiron (3)
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BUSPIRONE HYDROCHLORIDE
   
  ·        Class
  ¨    Antianxiety 
  ¨    Azaspirodecanedione 
  ·        Dosage, Adult (usual)
  ¨    Anxiety: 5 mg ORALLY 2-3 times a day OR 7.5 mg ORALLY twice a day; may increase the dosage by 5 mg/day every 2-3 days as needed (usual dose 20-30 mg/day (2-3 divided doses), MAX dose 60 mg/day) 
  ¨    Depression: 5 mg ORALLY 3 times a day; may increase the dosage by 5-10 mg/day every 2-3 days as needed (usual dose 40-55 mg/day (3 divided doses), MAX dose 90 mg/day) 
  ·        Dosage, Pediatric, (usual)
  ¨    safety and efficacy in children under the age of 18 has not been established 
  ·        Dose Adjustments:
  ¨    liver disease: clearance is decreased, use lower initial doses and increase gradually as needed and tolerated 
  ¨    renal impairment: clearance is decreased, use lower initial doses and increase gradually as needed and tolerated 
  ·        Administration
  ¨    ORAL: should be taken consistently, either always with food or always without food 
  ·        Monitoring
  ¨    reduction in symptoms of anxiety 
  ¨    signs and symptoms of withdrawal upon abrupt dose reduction or discontinuation 
  ·        How Supplied
  ¨    Oral Tablet: 5 MG, 7.5 MG, 10 MG, 15 MG, 30 MG 
  ·        Indications
  ¨    USFDA labeled indications
  §        Anxiety 
  ¨    Non-USFDA labeled indications
  §        Depression 
  ·        Contraindications
  ¨    hypersensitivity to buspirone products 
  ·        Precautions
  ¨    avoid drinking large amounts of grapefruit juice 
  ¨    buspirone will not block withdrawal symptoms in sedative/hypnotic/anxiolytic drug-dependent patients 
  ¨    concomitant use of an monoamine oxidase inhibitor 
  ¨    severe renal or hepatic impairment 
  ·        Adverse Effects
  ¨    COMMON
  §        Gastrointestinal: Nausea (3%) 
  §        Neurologic: Asthenia (2%), Confusion (2%), Dizziness (9%), Excitement (2%), Headache (3%), Numbness (2%) 
  §        Ophthalmic: Blurred vision (2%) 
  §        Psychiatric: Feeling angry (2%), Hostile behavior (2%), Nervousness (4%) 
  ¨    SERIOUS
  §        Cardiovascular: Congestive heart failure (rare), Myocardial infarction (rare) 
  §        Neurologic: Cerebrovascular accident (rare) 
     
     ·        Drug Interactions
  ¨    Clorgyline (major, theoretical) 
  ¨    Clozapine (major, probable) 
  ¨    Diltiazem (moderate, probable) 
  ¨    Erythromycin (moderate, probable) 
  ¨    Fluoxetine (moderate, probable) 
  ¨    Ginkgo (moderate, probable) 
  ¨    Iproniazid (major, probable) 
  ¨    Isocarboxazid (contraindicated, theoretical) 
  ¨    Itraconazole (moderate, probable) 
  ¨    Moclobemide (major, theoretical) 
  ¨    Nefazodone (moderate, probable) 
  ¨    Nialamide (major, probable) 
  ¨    Pargyline (major, probable) 
  ¨    Phenelzine (contraindicated, probable) 
  ¨    Procarbazine (major, probable) 
  ¨    Rifampin (moderate, probable) 
  ¨    Selegiline (major, theoretical) 
  ¨    St John's Wort (moderate, probable) 
  ¨    Toloxatone (major, probable) 
  ¨    Tranylcypromine (contraindicated, probable) 
  ¨    Verapamil (moderate, probable) 
  ·        Pregnancy Category
  ¨    Buspirone: B (Refer to USFDA's Pregnancy Risk table)
  ·        Breast Feeding
  ¨    Buspirone: Infant risk cannot be ruled out. 
   
  Source: Micromedex, Drugdex, Health Care Series, U.S.A


Dr. (Mrs.) Sampada Patvardhan (Ph.D.Tech. Pharmacology)
Director, Maharashtra State Pharmacy Council's Drug Information Centre India
E.S.I.S. Hospital Compound, L.B.S. Marg, Mulund (W), Mumbai-400 080
Phone: 25930607  Telefax: 25684291/25684418
e-mail: dicmspc@yahoo.co.in  OR dicmspc@hathway.com