[e-farmacos] WHO Drug Information n 4, vol 21, 2007

["Madurga, Mariano" <mmadurga@agemed.es>]

Estimadas y estimados,

La WHO acaba de publicar el ultimo numero del WHO Drug Information vol 21, n 4 de 2007, en el que se han celebrado las 3 decadas del modelo de Lista Medicamentos Esenciales (EML), con el siguiente indice:

Table of Contents:

Access to Essential Medicines 
WHO celebrates thirty years of essential medicines      267 

Pharmacovigilance Focus 
Estrogen therapy and symptoms of parkinsonism: a review using 
WHO's ADR data base     270 

Safety and Efficacy Issues 
Perflutren injectable: serious cardiopulmonary reactions        281 
Gefitinib: failure of overall survival vs docetaxel             281 
Rituximab and progressive multifocal leukoencephalopathy        282 
Implanon®: interactions and contraceptive failure               283 
Atypical antipsychotic agents and extrapyramidal effects        283 
Thiazolidinediones and reduced bone density                     284 
Renal impairment with zoledronic acid                           285 
Epoetins: unexplained excess mortality                          285 
Contraindicated use of sibutramine and cardiovascular reactions 287 
Gadolinium-containing contrast agents: nephrogenic systemic fibrosis 287 
Swedish Adjustable Gastric Band: incidents leading to explantation 288 

Regulatory Action and News 
Influenza virus vaccines: Southern hemisphere 2008              290 
Withdrawal of cough medicines containing clobutinol?            290 
Rimonabant warning: psychiatric conditions                      290 
Lumiracoxib registration cancelled                              291 
Lumiracoxib: withdrawal of higher doses                         291 
Ixabepilone approved for advanced breast cancer                 292 
Second-generation smallpox vaccine approved                     292 
Regulatory updates                                              293 

Generic Medicines 
Generic substitution in Jamaica: challenges to improving effectiveness 294 
Frequently asked questions about generic medicines              300 

Quality Assurance Update 
Latest developments in ICH quality      304 

Consultation Documents 
International Pharmacopoeia 
Oxytocin                                        309 
Oxytocin injection                              313 
Recent Publications, Information and Events 
GMP for herbal medicines                        315 
Quality of antiretrovirals in African countries 315 
The Health Journey                              315 
Human rights guidelines for pharmaceutical companies 316 
ARV price report from WHO                       316 

Proposed International Nonproprietary Names: List 98 317 

Proximamente se podra consultar en la web:
http://www.who.int/druginformation <http://correoweb.msc.es/exchweb/bin/redir.asp?URL=http://www.who.int/druginformation>  

Un abrazo y ¡¡¡¡Feliz 2008!!!!,

Mariano Madurga Sanz
Jefe de Servicio de Coordinacion del SEFV
Division de Farmacoepidemiologia y Farmacovigilancia
Agencia Espanhola de Medicamentos y Productos Sanitarios
mmadurga@agemed.es