[e-farmacos] WHO Pharmaceut Newsletter, n 5 , 2007

["Madurga, Mariano" <mmadurga@agemed.es>]

Estimadas y estimados,

La WHO acaba de publicar el ultimo numero del WHO Pharmaceuticals Newsletter, n 5 , 2007, con el siguiente indice:

Regulatory Matters 
Clobutinol-containing cough preparations-Withdrawn due to adverse cardiac effects ...1 
Ephedrine and pseudoephedrine containing nasal decongestants -- OTC products to have tighter controls ...1 
Exenatide -- Reports of acute pancreatitis; label to be updated ...1 
Haloperidol -- Labelling updated with risk of torsades de pointe ... 2 
Lumiracoxib -- Risk of serious hepatotoxicity ... 2 
Nelfinavir -- Guidance on process impurity in North America; licence re-established in Europe ...3
Nimesulide -- Restricted use recommended ... 4 
PDE5 Inhibitors -- Reports of sudden decreases in or loss of hearing ... 4 
Pergolide -- Withdrawn in Canada ... 5 
Talc preparations for pleurodesis -- To be treated as medicines ... 5 

Safety of Medicines
Atypical antipsychotics -- Not free of extrapyramidal side effects ...6 
Bisphosphonates -- Review of early data of atrial fibrillation ...6 
Calabash chalk -- May pose health risk for pregnant and breastfeeding women ...6 
Colloidal silver -- Health risks associated with chronic ingestion ... 6 
Duloxetine -- Risk of suicidal ideation ... 7 
Etonogestrel -- Reports of unintended pregnancy ... 7 
Fentanyl buccal tablets -- Deaths due to improper use ... 7 
Lopinavir/ritonavir -- Caution against accidental overdose in children ...8 
Sibutramine -- Contraindications to be strictly followed... 8 
Zoledronic acid -- Should only be given intravenously ... 9 
Zolpidem -- Reports of sleep-walking .. .9 

Feature Report of a WHO Training Course on Pharmacovigilance for Consultants ...10

Proximamente se podra consultar en la web:
http://www.who.int/medicines/publications/newsletter/en/ 

Un abrazo,

Mariano Madurga Sanz
Jefe de Servicio de Coordinacion del SEFV
Division de Farmacoepidemiologia y Farmacovigilancia
Agencia Espanhola de Medicamentos y Productos Sanitarios
mmadurga@agemed.es