[e-farmacos] BMJ: RAM anecdoticas

["Madurga, Mariano" <mmadurga@agemed.es>]

Estimadas y estimados,

En el BMJ del 15-12-2006 aparece un articulo breve de Aronson JK y col, titulado: "Anecdotes that provide definitive evidence", sobre las situaciones de ciertas RAM que siendo anecdoticas soportan la prueba de asociacion causal. 

Transcribo los 4 tipos de RAM que se comentan:

We have identified four types of spontaneously reported adverse events for which causal or contributory attribution to the drug is either irrefutable or demonstrable with a high level of confidence (table\l
"TBL1" \l "TBL1"):
*       Extracellular or intracellular tissue deposition of the drug or a metabolite
*       Specific anatomical location or pattern of injury
*       Physiological dysfunction or direct tissue damage that can be proved by physicochemical testing
*       Infection as a result of administration of a potentially infective agent or because of demonstrable contamination.

In each case the diagnosis can be established definitively, or with a high degree of certainty, in the individual patient. In some cases the diagnostic value of the event can be enhanced by further investigation, but the conclusion will always be related to the person affected.

El texto compelto en la web del BMJ: http://www.bmj.com/cgi/reprint/333/7581/1267

Un abrazo,

Mariano Madurga
Agencia Espanhola de Medicamentos y Prod Sanitarios
mmadurga@agemed.es