[e-farmacos] Cox2 en el JAMA

["Canas, Martin" <macanas@netverk.com.ar>]

Estimadas y estimados,

Un revision sistematica de estudios observacionales, un metanalisis de ensayos clinicos y un editorial de David Graham sobre COX2 en el JAMA,
para el debate sobre todo el comentario de Graham al tan ultimamente promocionado estudio MEDAL con etoricoxib que pugna por su aprobacion por la FDA.

Patricia McGettigan; David Henry
Cardiovascular Risk and Inhibition of Cyclooxygenase: A Systematic Review 
of the Observational Studies of Selective and Nonselective Inhibitors of 
Cyclooxygenase 2
JAMA published 12 September 2006, 10.1001/jama.296.13.jrv60011
http://jama.ama-assn.org/cgi/content/abstract/296.13.jrv60011v1?etoc

Jingjing Zhang; Eric L. Ding; Yiqing Song
Adverse Effects of Cyclooxygenase 2 Inhibitors on Renal and Arrhythmia 
Events: Meta-analysis of Randomized Trials
JAMA published 12 September 2006, 10.1001/jama.296.13.jrv60015
 http://jama.ama-assn.org/cgi/content/abstract/296.13.jrv60015v1?etoc

David J. Graham COX-2 Inhibitors, Other NSAIDs, and Cardiovascular Risk: The Seduction of Common Sense
JAMA published 12 September 2006, 10.1001/jama.296.13.jed60058
 http://jama.ama-assn.org/cgi/content/full/296.13.jed60058v1?etoc

Saludos,

Martin

Martin Canas
La Plata 
(Argentina)
macanas@netverk.com.ar