[e-farmacos] Lancet: AINE reducen cancer bucal pero mas efectos CV

["Madurga, Mariano" <mmadurga@agemed.es>]

Estimadas y estimados amigos,
 
Entre la publicaciones online anticipadas de LANCET se encuentra hoy una importante: un estudio Noruego (CONOR) en el que se constata una reduccion de la frecuencia de cancer bucal en fumadores que usan AINEs, pero en los que se incrementa la frecuencia de efectos CV, de 7% (no usuarios) al 16% en usuarios de AINEs:

La direccion:
http://www.thelancet.com/journals/lancet/article/PIIS0140673605674880/abstract?isEOP=true

Non-steroidal anti-inflammatory drugs and the risk of oral cancer: a nested case-control study. J Sudbø,JJ Lee,SM Lippman,J Mork,S Sagen, N Flatner, A Ristimäki, A Sudbø,L Mao,X Zhou,W Kildal,JF Evensen,A Reith and AJ Dannenberg. The Lancet Early Online Publication, 7 October 2005 
DOI:10.1016/S0140-6736(05)67488-0

Noticia en el Daily Mail, 7 October 2005
 
Long-term use of aspirin-like drugs reduces the risk of mouth cancer in smokers but raises the chances of death from heart disease, according to researchers. 
Previous studies had suggested that the medicines, called non-steroidal anti-inflammatory drugs (NSAIDs), could help prevent several types of cancer. 

But prolonged use of such drugs has also been shown to cause heart problems. 

Researchers in Norway studied 454 people with mouth cancer from a group of 9,241 heavy smokers. 

They were matched against a similar number of heavy smokers who did not have mouth cancer. 

A total of 263 participants used NSAIDs, which were found to reduce the risk of mouth cancer by 53%, even in active smokers. 

The protective effect was comparable with that of giving up smoking. 

But the investigators also found that long-term use of NSAIDs doubled the relative risk of death due to heart disease. 

A total of 16% of NSAID users died of cardiovascular events, compared with 7% of non-users. 
 

Un abrazo,

Mariano Madurga
Agencia Espanhola de Medicamemntos y Productos Sanitarios
mmadurga@agemed.es
www.agemed.es