[e-farmacos] WHO Pharmaceutical Newsletter num 3, 2005

["Canas, Martin" <macanas@netverk.com.ar>]

Estimadas y estimados,

Esta disponible el WHO Pharmaceutical Newsletter num 3, 2005 en:
http://www.who.int/medicines/library/pnewslet/pn2005_3.pdf

Contenido:
Regulatory Matters
Albumin -- Safety issues in critically ill patients,. 1
Antiretroviral agents -- Caution advised against certain combinations ,. 1
Atypical Antipsychotics - Risk of death in elderly patients with dementia, 1
Cyclooxygenase-2 (COX-2) Inhibitors -- To be available under strict restrictions,. 2
Cyproterone acetate and ethinylestradiol -- Not to be used in contraception, 2
Donepezil -- Warning of rhabdomyolysis, 2
Drotrecogin alfa (activated) -- Only for use in high-risk patients, 3
Efavirenz -- Reports of neural tube defects, 3
Efalizumab -- Immune mediated haemolytic anaemia, 3
Galantamine -- Death in subjects with mild cognitive impairment, 3
Hydromorphone hydrochloride -- To be withdrawn for safety reasons, 3
Lepirudin -- Information on dosage and administration, 4
Mitoxantrone -- Label to reflect risks of cardiotoxicity, 4
NSAIDs -- Black box warning for both prescription and OTC products, 4
Oxcarbazepine -- Label to include serious dermatological reactions,  5
Paroxetine and Pimozide -- Concurrent use contraindicated, 5
Phenylpropanolamine -- Suspended while adverse reaction reports are reviewed, 5
Sildenafil, Tadalafil, Vardenafil -- Labels updated with NAION information, 5
Valdecoxib -- Sales suspended in more countries, 6
Veralipride -- Suspended due to neurological and other adverse reactions, 6

Safety of Medicines
Angiotensin converting enzyme (ACE)-Inhibitors -- Continuing reports of angioedema, 7
Anticonvulsants -- Drug-suicide link to be reviewed, 7
Ayurvedic Medicines -- Some contain high levels of heavy metals, 7
Antidepressants -- Monitoring adults for suicidality, 7
Antidepressants -- Use in children, 7
Dextromethorphan -- Abuse may be deadly, 8
Fentanyl transdermal patches -- Safety warnings regarding use, 8
Fluorescein -- Recommendations for safe use, 8
Interferon alfa-2b -- Reports of osteonecrosis, 9
Isotretinoin -- Update on reports of suicidal thoughts, 9
Mifepristone and misoprostol -- Reports of septic deaths, 9
Nesiritide -- Recommendations for appropriate use, 10
Reboxetine -- Genitourinary adverse effects, 10
Statins -- Reports of peripheral neuropathy, 10

Miscellany
WHO Prequalification Project, 11
Draft Agenda - Twenty-eighth Annual Meeting of Representatives of National Centres participating in the WHO International Drug Monitoring Programme, 12


Saludos,

Martin

Martin Canas
GAPURMED
La Plata
(Argentina)
macanas@netverk.com.ar