[e-farmacos] Otros inhibidores de la COX 2?

["Piola, Juan Carlos" <jpiola@sertox.com.ar>]

Esta informacion que me envia un farmacologo amigo puede ayudar a responder la inquietud de Carlos Ramirez. Se puede acceder en:

http://www.hc-sc.gc.ca/hpfb-dgpsa/tpd-dpt/adrv12n2_table2_e.html.

Table 2: Reports submitted to Health Canada on types of suspected cardiovascular / cerebrovascular ARs associated with selective COX-2 inhibitors from date marketed to Oct. 12, 2001*


Atentamente,

Juan Carlos Piola
Rosario, Santa Fe
(Argentina)


Table 2: Reports submitted to Health Canada on types of suspected cardiovascular/cerebrovascular ARs associated with selective COX-2 inhibitors from date marketed to Oct. 12, 2001*

Drug; no. of reactions
Type of reaction / Celecoxib / Rofecoxib / Meloxicam
Increased blood pressure / 20 / 21 / 1
Congestive heart failure / 7 / 17 / -
Myocardial infarction? / 8 / 9 / 1
Angina / - / 2 / -
Heart rate and rhythm disorders? / 24 / 20 / -
Cerebrovascular events due
  to hemorrhage or cause non specified§ / 9 / 9 / -
Cerebrovascular events with clot / 1 / - / -
Thromboembolic events¶ / 8 / - / -
Pericardial effusion / 1 / - / -
Endocarditis / 1 / - / -
Aortic aneurysm rupture / 1 / - / -
Vasculitis / 3 / - / -

*This table reports reactions, and each report may contain more than 1 reaction. These data cannot be used to determine the incidence of ARs because neither patient exposure nor the amount of time the drug was on the market has been taken into consideration.
? Includes myocardial ischemia.
? Includes cardiac arrest, cardiac arrhythmia, atrial fibrillation, ventricular fibrillation, heart block, sick sinus syndrome, tachycardia, ventricular tachycardia, palpitation, bradycardia.
§ Includes cerebrovascular accident, stroke, transient ischemic attack.
¶ Includes pulmonary embolism, deep vein thrombosis, venous arm thrombosis, limb embolism, peripheral ischemia.

Last updated - 2003-01-27