[e-farmacos] Ibuprofeno inyectable (cont.)

["Domosbian, Daniel" <cimf@colfarma.org.ar>]

E-farmacos: Ibuprofeno inyectable (cont.)
------------------------------------------------------

Nosotros tambien estuvimos buscando informacion sobre
el ibuprofeno inyectable y parece que en China lo
usan, debido a que encontramos estas referencias:

Study of ibuprofen-L-lysine injection. Jia-YR; Li-TL;
Chu-Y. West China Univ. of Med. Sci., Chengdu 610041,
China. Chin-J-Hosp-Pharm-Yiyuan-Yaoxue-Zazhi 
(Chinese-Journal-of-Hospital-Pharmacy); 1995; 15(Dec);
532-534  
AB: The stability of an ibuprofen-L-lysine (ibuprofen
lysinate) injection was investigated after exposure to
light for 10 days, after exposure to 60 and 80DGC
temperatures for 10 days, and after exposure to 40DGC 
for 3 months, and it was compared to dipyrone
(Analgin) injection in animals.  No significant
changes were observed except that the content 
became slightly lower after exposure to light. An
effect test with experimental animals showed that the
injection was a more effective antipyretic, analgesic,
and anti-inflammatory agent than dipyrone injection at

similar doses. 

Preparation of ibuprofen lysine and its injection
Luan-LB; Zhang-JS; Zhu-JB Div. of Pharmaceutics, China
Pharm. Univ., Nanjing 210009, China
J-China-Pharm-Univ-Zhongguo-Yaoke-Daxue-Xuebao
(Journal-of-the-China-Pharmaceutical-University);
1994; 25(Apr); 80-82 
AB: The synthesis of ibuprofen lysinate (ibuprofen
lysine) injection is described and evaluated for
stability after storage for up to 2 yr. Results
indicated that the injection is stable when stored
under ambient conditions for 2 yr. 

Atentamente,

Daniel Domosbian
Centro de Informacion de Medicamentos Farmaceutico
Colegio de Farmaceuticos de la Provincia de Buenos
Aires
cimf@colfarma.org.ar

[NOTA: Mensaje sin acentos ni caracteres especiales.]
























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