[e-drug] Compounded drug warnings issued on hormones; inhalation meds (2)

["Brent Murphy" <pharmacist@finepharmaceuticals.com>]

E-DRUG: Compounded drug warnings issued on hormones; inhalation meds (2)
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Dear E-druggers,

There are certainly some advantages to compounded bio-identical hormones
which this article fails to mention:

*	Emphasis on topical (transdermal) administration; avoids problems
such as blood clotting that are caused by the rapid metabolism of orally
administered hormones (PMID
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=A
bstract&list_uids=12927428>  12927428). 
*	Bio-identical Progesterone may work differently in the body than
medroxyprogesterone acetate (PMID
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=A
bstract&list_uids=15358673>  15358673). 
*	Emphasis on individualised doses rather than "one dose fits all"
approach of conventional hormone replacement therapy (PMID
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=A
bstract&list_uids=12478948>  12478948). 
*	Inclusion of bio-identical estriol may be protective against
hormone-induced cancer. Unlike estradiol, estriol binds preferentially to
the second estrogen receptor (ERbeta). ERbeta may function as a tumor
suppressor (PMID
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=A
bstract&list_uids=15369453>  15369453). 
*	Allows for the incorporation of unconventional hormones such as DHEA
(dehydroepiandrosterone) which have unique benefits
(http://www.thorne.com/altmedrev/.fulltext/6/3/314.pdf)

Kindest regards

Brent Murphy - B.Pharm (Rhodes), MPS
Pharmacist
Fine Pharmaceuticals
South Africa
pharmacist@finepharmaceuticals.com