[e-drug] Drugs with narrow therapeutic index (cont'd)

[Perla Mordujovich <pmordujo@netverk.com.ar>]

E-drug: Drugs with narrow therapeutic index (cont'd)
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Dear E-druggers,

With respect to Daniel's inquiry about medicines with a narrow
therapeutic index, here is a list with some examples:

Anticonvulsants (phenytoin)
Oral hypoglycemic medicines (glibenclamide)
Oral anticoagulants (acenocumarol, warfarin)
Antifungals (amphotericin B)
Anthydisrhythmic medicines (quinidine)
Aminoglycosides (gentamicin)
Anticancer medicines (5 fluorouracil)
Digitalis glycosides (digoxine)
Lithium carbonate
Immunosuppressive medicines (cyclosporine)
Antiretrovirals (zidovudine)
Theophylline

References: Textbooks of Pharmacology and Therapeutics
(Goodman and Gilman, Melmon and Morelli, Avery's Drug
Treatment, etc).

Best wishes,

Perla M Bucshiazzo
Department of Pharmacology
School of Medicine
National University of La Plata
Argentina
e-mail: pmordujo@netverk.com.ar

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